The Microsystems Design Lab was founded in 1977 at The Pennsylvania State University by Prof. Mary Jane Irwin. The current co-directors of the center include Dr. Vijaykrishnan Narayanan, Dr. Mahmut Kandemir, and Dr. Jack Sampson. Former lab co-directors include Prof. Robert E. Owens (deceased), Prof. Yuan Xie, and Prof. Mary Jane Irwin. The Lab has more than 200 alumni.

Microsystems design lab is also a part of The Center for Artificial Intelligence Foundations and Engineered Systems (CAFE), pronounced café directed by Dr. Vijaykrishnan Narayanan, brings together expertise from 75 researchers representing 24 academic units across Penn State with the goal of developing cross-disciplinary interactions for advancing AI foundations. 

The lab has produced unique artifacts such as the MGAP2, Arithmetic Cube, SPARTAN, TANOR, NeoVision 2 special purpose computers; widely used design automation tools such as Simplepower, NVSim and 3D-Cacti; and groundbreaking technologies such as Dual-Vdd FPGAs and leakage power management.

The lab has many exciting projects in the areas of intelligent computer architectures, ultra-low power computing, hardware security, data center computing, software systems for memory and storage and emerging devices, circuits and systems.